2022; 5(2): 1-10
DOI: 10.32114/CCI.2022.5.2.1.10
Published online: 2022-06-30 (first online 2022-04-16)
Evaluation of patients with candida infections in a tertiary care hospital’s general intensive care unit in Turkey.
İlkay Ceylan [1]
,
Hamide Ayben Korkmaz [1] ,
Ebru Karakoç [2] .
[1] Bursa Yüksek İhtisas Training and Research Hospital, Department of Anesthesiology and Reanimation, Bursa, Turkey.
[2] PEskişehir Osmangazi University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Eskişehir, Turkey
Abstract:
Abstract [EN] - INTRODUCTION: : Studies indicate that approximately 90% of the patients followed in the ICU have Candida spp
colonization. In this study we aimed to elucidate the epidemiology, characteristics, management and outcomes of
patients with candidemia in the intensive care unit of a training and research hospital.
MATERIAL AND METHODS: All patients over the age of 18 who were hospitalized in general intensive care unit
more than 24 hours between 2013 and 2019 were included in the this retrospective study.
RESULTS: A total of 43 critically ill patients with blood cultures positive for Candida spp. have been enrolled in this
retrospective analysis. The duration of stay in the intensive care unit of the survivors was approximately 53 days,
while the average length of stay in the intensive care unit of the non survivors was 16 days, and this difference was
statistically significant (p<0.05), 89.7% of septic patients with candidemia died the intensive care unit. There was a
statistically significant difference between the two groups in terms of platelets, urea and systolic blood pressure
(p<0.05), the mean platelet and systolic blood pressure values of the surviving patients were higher than the
deceased individuals, while the urea value was lower. The average fungal growth time of the surviving individuals
was 17 days, while this period was 1 day in the non-survivor patients.
CONCLUSIONS: The mortality rate was higher in patients with sepsis and concomittant candida infection at very
soon days of ICU hospitalization. Early administration of empirical antifungal therapy with coverage of non-albicans
should be considered for septic patients.
Streszczenie [PL] - WSTĘP: Badania wskazują, że około 90% pacjentów obserwowanych na OIOM ma kolonizację Candida spp.
W tym badaniu mieliśmy na celu wyjaśnienie epidemiologii, charakterystyki, zarządzania i wyników
pacjentów z kandydemią na oddziale intensywnej terapii szpitala szkoleniowo-badawczego.
MATERIAŁ I METODY: Do tego retrospektywnego badania włączono wszystkich pacjentów powyżej 18 roku życia, którzy byli hospitalizowani na oddziale intensywnej terapii ogólnej dłużej niż 24 godziny w latach 2013-2019.
WYNIKI: Łącznie 43 krytycznie chorych pacjentów z dodatnimi posiewami krwi na Candida spp. zostało włączonych do
analizy retrospektywnej. Czas pobytu na oddziale intensywnej terapii dla ocalałych wynosił około 53 dni, podczas gdy średni czas pobytu na oddziale intensywnej terapii dla ocalałych wynosił 16 dni, a różnica ta była istotna statystycznie (p<0,05). 89,7% septycznych pacjentów z kandydemią zmarło na oddziale intensywnej terapii. Wykazano
statystycznie istotną różnicę między obiema grupami w zakresie płytek krwi, mocznika i skurczowego ciśnienia krwi
(p<0,05). Średnie wartości ciśnienia krwi u pacjentów, którzy przeżyli, były wyższe niż
zmarłych, natomiast zawartość mocznika była niższa. Średni czas wzrostu grzybów osobników, które przeżyły
wynosił 17 dni, podczas gdy u pacjentów, którzy nie przeżyli, okres ten wynosił 1 dzień.
WNIOSKI: Śmiertelność była wyższa u pacjentów z sepsą i współistniejącym zakażeniem drożdżakami w bardzo krótkim czasie hospitalizacji na OIT. U pacjentów z posocznicą należy rozważyć wczesne zastosowanie empirycznego leczenia przeciwgrzybiczego, obejmującego także osoby nie zakażone.
Citation:
VANCOUVER FORMAT
Ceylan İ, Korkmaz HA, Karakoç E. Evaluation of patients with candida infections in a tertiary care hospital’s general intensive care unit in Turkey.
Crit. Care Innov. 2022; 5(2): 1-10.
DOI: 10.32114/CCI.2022.5.2.1.10
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